Fault Tree

OBD-II differential diagnosis

P0301 — Cylinder 1 misfire detected

One cylinder is not burning its fuel properly. Unburnt fuel goes into the exhaust and can destroy the catalytic converter in a few hundred miles, which turns a cheap repair into an expensive one.
System
Powertrain
Definition
Generic (SAE-defined, all manufacturers)
Subsystem
Ignition system or misfire
Severity
severe

Causes, by prior probability

CausePriorRepair
Ignition coil, cylinder 1
Swap the coil to another cylinder. If the misfire follows, the coil is the fault.
34% $135
Spark plug, cylinder 1
Pull and inspect. Check gap and insulator colour against the others.
28% $85
Fuel injector, cylinder 1
Listen with a stethoscope for a clicking injector; measure coil resistance.
16% $344
Low compression, cylinder 1
Compression and leak-down test. This is the diagnosis that changes the economics of the whole repair.
13% $213
Vacuum leak local to cylinder 1
Smoke test with attention to the runner for cylinder 1.
9% $180
These are priors from the code alone. A scan's freeze frame reorders them, which is the entire point of capturing it.